Introduction and Motivation. As biomechanical properties of tissues are tightly linked to pathologies, the description of mechanical tissue properties is instrumental to advance our understanding of disease development and progression. Pathology often manifests through the alteration of tissue mechanical properties long before clinical imaging modalities are able to see any structural or functional changes. Formed by cells embedded in the Extra Cellular Matrix (ECM), biological tissue exhibits intricate microstructural characteristics, factors that then govern its micro-mechanical and macro-mechanical properties. The analysis of how load (stress and strain) transmits across said scales and therefore stimulates cell function, is challenging and requires trustworthy biomechanical models. A plethora of mechanical testing has been reported, and, as no testing standards for biological tissue exist - individual laboratories implement individual protocols. A similar observation characterizes the design of biomechanical computational models. Besides hindering the cross-comparison, low-quality experimental data as well as poor biomechanical models challenge the exploration of biological phenomena. In conclusion, the biomechanical community requires an educational program to develop a solid foundation in the analysis of biological tissues. It is the proper integration of experimental tissue characterization and computational biomechanical analysis that guarantees progress in the field.
Faculty
Module I: Basics Wednesday, Aug. 12th 8.00-9.00: Registration to Modul I 9.00-12.00 Continuum mechanics 12.00-14.00 Lunch break 14.00-17.00 Continuum mechanics Thursday, Aug. 13th 9.00-12.00 Finite element method 12.00-14.00 Lunch break 14.00-17.00 Finite element method Friday, Aug. 14th 9.00-12.00 Constitutive modeling 12.00-14.00 Lunch break 14.00-17.00 Constitutive modeling Module II: Applications Monday, Aug. 17th 8.15-10.15 Non-linear Continuum Biomechanics 10.15-10.45 Coffee break 10.45-12.45 Constitutive modeling 12.45-14.00 Lunch break 14.00-15.15 Ask the expert 15.30-18.00 In-vitro tissue testing (group 1) 15.30-18.00 FEM modelling (group 2) Tuesday, Aug. 18th 8.15-10.15 Data Analysis 10.15-10.45 Coffee break 10.45-12.45 Vascular tissue 12.45-14.00 Lunch break 14.00-15.15 Ask the expert 15.30-18.00 In-vitro tissue testing (group 2) 15.30-18.00 FEM modelling (group 3) Wednesday, Aug. 19th 8.15-10.15 Bone 10.15-10.45 Coffee break 10.45-12.45 Tendon, Ligament, Cartilage 12.45-14.00 Lunch break 14.00-15.15 Ask the expert 15.30-18.00 In-vitro tissue testing (group 3) 15.30-18.00 FEM modelling (group 4) Thursday, Aug. 20th 8.15-10.15 The basics of non-invasive clinical imaging modalities 10.15-10.45 Coffee break 10.45-12.45 ex-vivo tomography 12.45-14.00 Lunch break 14.00-15.15 Ask the expert 15.30-18.00 In-vitro tissue testing (group 4) 15.30-18.00 FEM modelling (group 1) Friday, Aug. 21st 8.15-10.15 Brain/head 10.15-10.45 Coffee break 10.45-11.15 Ask the expert 11.15-13.30 Lunch break 13.30-15.00 Multiple choice test in groups of four students Social activities Sunday, Aug.16th 17.30-18.30 Boat tour through The Royal National City Park and registration to Module II Monday, Aug. 17th 16.00-17.00 Guided tour around KTH campus (group 3) Tuesday, Aug. 18th 16.00-17.00 Guided tour in Nobel Prize Museum (group 1) Wednesday, Aug. 19th 16.00-17.00 Guided tour around KTH campus (group 1,2) Thursday, Aug. 20th 16.00-17.00 Guided tour in Nobel Prize Museum (group 2,3) 19.30-22.15 Dinner Friday, Aug. 21st 20.00- Pub night
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